The intermediate role of carbamyl-L-glutamic acid in citrulline synthesis.
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چکیده
منابع مشابه
Metabolic Functions of Biotin Iv. the Role of Carbamyl-l-glutamic Acid in the Synthesis of Citrulline by Normal and Biotin-deficient Rats* by Gladys Feldott
A characteristic consequence of a biotin deficiency in animals is a decreased ability to fix C402 into various tissue components including the amino acid arginine (1). Carbon dioxide is incorporated into arginine as a result of the conversion of ornithine to citrulline in the Krebs-Henseleit urea cycle (2). The methods developed by Cohen and Hayano (3, 4) for the synthesis of citrulline from or...
متن کاملMetabolic functions of biotin. IV. The rôle of carbamyl-l-glutamic acid in the synthesis of citrulline by normal and biotin-deficient rats.
A characteristic consequence of a biotin deficiency in animals is a decreased ability to fix C402 into various tissue components including the amino acid arginine (1). Carbon dioxide is incorporated into arginine as a result of the conversion of ornithine to citrulline in the Krebs-Henseleit urea cycle (2). The methods developed by Cohen and Hayano (3, 4) for the synthesis of citrulline from or...
متن کاملCarbon dioxide and ammonia fixation in the biosynthesis of citrulline.
In the preceding paper (1) an enzyme preparation was described which catalyzed the synthesis of citrulline from ornithine in the presence of adenosinetriphosphate (ATP), ammonia, magnesium and bicarbonate ions, and carbamylglutamate. Glutamic acid could not replace the latter compound. Balance studies have failed to provide satisfactory evidence for the r61e of carbamylglutamate in this system....
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A carbamyl phosphate synthetase has been detected and partially characterized in hepatopancreas tissue of the land snail Strophocheitus oblongus. The enzyme is localized in mitochondria, utilizes L-glutamine, and shows an absolute requirement for N-acetyl-L-glutamate. This unique combination of properties distinguishes the snail enzyme from either of the previously described animal carbamyl pho...
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The influence of ammonia and inhibition of the urea cycle by norvaline on orotic acid synthesis in five Polish Merino ewes was investigated. The sheep were exposed to 60 min of successive infusions of 0.9% NaCl, NH4Cl (20 mumol kg-1 min-1), and NH4Cl with DL-norvaline (10 mumol kg-1 min-1) solutions administered to the mesenteric vein. The average rate of orotic acid output, urea output and amm...
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 174 1 شماره
صفحات -
تاریخ انتشار 1948